The measure tells the tale: Clinical outcome measures in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Outcome Measures in Multiple Sclerosis
The acquisition of a reliable and valid outcome measure in multiple sclerosis (MS) is one of the holy grails for clinician researchers working in the field. The current standard for measuring MS-related disability is the Expanded Disability Status Scale (EDSS), a nonlinear scale ranging from 0 (normal neurologic examination) to 10 (death due to MS) [1]. Widely incorporated into MS clinical tria...
متن کاملOutcome Measures in Clinical Trials for Multiple Sclerosis
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess the true efficacy of interventions in clinical trials. In phase III trials in MS, the traditionally used primary clinical outcome measures are the Expanded Disability Status Scale and the relapse rate. Seco...
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Patient-reported outcome (PRO) measures are being used more frequently in epidemiological studies, health service research and in clinical trials to evaluate therapeutic interventions from the patient's perspective. In MS, where evaluations of treatments are becoming increasingly important, outcome measures that are rigorous and appropriate to patients are needed. This article examines the valu...
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With the advent and widespread use of partially effective disease modifying drug therapies for multiple sderosis (MS), future dinical trials will undoubtedly test experimental interventions against standard therapy, or will test combinations of drugs against standard therapy. In either case, incremental progress in slowing disability progression in future MS dinical trials will require much lar...
متن کاملThe Role of Clinical and Instrumented Outcome Measures in Balance Control of Individuals with Multiple Sclerosis
Purpose. The aim of the study was to investigate differences in balance control between individuals with multiple sclerosis (MS) and healthy control subjects using clinical scales and instrumented measures of balance and determine relationships between balance measures, fatigue, and disability levels in individuals with MS with and without a history of falls. Method. Twelve individuals with MS ...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2017
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458517690825